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This was determined using a constant routine, and shifts in the midpoint of melatonin secretion (melatonin midpoint) rather than DLMO were measured following a single pulse of light

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Materials and methods Animal model of CME and in vivo treatment Adult male SpragueDawley rats (approximately 250 g) were obtained from the Animal Center of Guangxi Medical University (Nanning, China)

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Lab-on-a-chip models of the bloodbrain barrier: evolution, problems, perspectives